Ripk2 CLIA Kit for Mouse(Mus musculus) | EIAab.comRipk2 CLIA Kit for Mouse(Mus musculus)

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Ripk2 (Gene name),

Receptor-interacting serine/threonine-protein kinase 2 (Protein name ), RIPK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ripk2;

Protein name:

Receptor-interacting serine/threonine-protein kinase 2;

Alternative:

2.7.10.2;Tyrosine-protein kinase RIPK2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1 and NOD2. Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway. Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1.

Function:

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

539

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

539:

AKVVVQKLKD | NKQLGLQPYP | EVPVLSKAPP | SNFPQNKSL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P58801

KEGG:

mmu:192656

UniGene:

Mm.112765

String:

P58801

Pfam:

PF00619

Uniprot:

P58801

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ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

E1786h

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Manual:

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96T

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ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

MSDS:

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ELISA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

E1786m

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Packing:

96T

CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

U1786m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

MSDS:

Please sign in first.

CLIA Kit for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

U1786h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

P1786Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 2

Cat.:

P1786Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Receptor-interacting serine/threonine-protein kinase 2

Protein for Mouse Receptor-interacting serine/threonine-protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Involvement of receptor-interacting protein 2 in innate and adaptive immune responses."
Chin A.I. , Dempsey P.W. , Bruhn K. , Miller J.F. , Xu Y. , Cheng G.
Nature416:190-194(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: 129.
tissue: Mammary gland.
3.

"RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs."
Park J.H. , Kim Y.G. , McDonald C. , Kanneganti T.D. , Hasegawa M. , Body-Malapel M. , Inohara N. , Nunez G.
J. Immunol.178:2380-2386(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
4.

"The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens."
Hsu Y.M. , Zhang Y. , You Y. , Wang D. , Li H. , Duramad O. , Qin X.F. , Dong C. , Lin X.
Nat. Immunol.8:198-205(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARD9
5.

"Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands."
Magalhaes J.G. , Lee J. , Geddes K. , Rubino S. , Philpott D.J. , Girardin S.E.
Eur. J. Immunol.41:1445-1455(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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